Dear Aspirants,
Sub: PGDHHM: One year evening programme, offered by PESIT in association with Hosmac Foundation for healthcare professionals.
Warm greetings…………..
Hosmac Foundation – an affiliation of Hosmac India Private Limited, proudly announces to commence one year – evening programme –Post graduate diploma in hospital and healthcare management (PGDHHM) in association with PES IT, an autonomous institute under VTU, Bangalore.
This certification programme is being conducted at PESIT Campus, Banashankari III rd stage, Bangalore 560085, between 5.30pm and 8.30pm, five days a week.
The course is due to be starting from 25th August and the last day for submission of the application is 14th August.
We are conducting orientation sessions on request at our office in Bangalore for prospective students who wish to understand the details of the course, career growth, job placements and alternative career pathways. We also brief candidates in detail about the demanding healthcare needs in future and a place for such Professionals in India.
For further details please contact
Dr.(Major) Madhu (No- 9980154883)
Dr. Jithendra Kumar (No- 9980137821) and
Mr. Rajesh (No.9731164416) or
you could send mail to pgdhhm.pesit@hosmacfoundation.org for details along with your contact number so that we can brief you the course details.
Please visit www.hosmacfoundation.org and www.pes.edu
Thanks and Regards.
Hosmac India Pvt Ltd
Sai Dham #95, IV Main, HAL II Stage
Behind Leela Palace, Kodihalli
Bangalore- 560008
India
Monday, July 28, 2008
Friday, July 25, 2008
General Surgeon Wanted in West Indies
Dear nellai medicos
regards
well i am a chief surgeon govt of west indies
i want a fresh young general surgeon [M S] from south as my assistant
if any one is willing please contact my mail id
he 'll get very bright future and a chance to settle in USA
the detail after his interested and detailed C V
BASSICALLY I AM FROM TIRUNELVELI it is to help someone from south
DR KRISHNA
subbiahradha@hotmail.com
regards
well i am a chief surgeon govt of west indies
i want a fresh young general surgeon [M S] from south as my assistant
if any one is willing please contact my mail id
he 'll get very bright future and a chance to settle in USA
the detail after his interested and detailed C V
BASSICALLY I AM FROM TIRUNELVELI it is to help someone from south
DR KRISHNA
subbiahradha@hotmail.com
Monday, July 21, 2008
CALL FOR ABSTRACTS: Global Health & Development Conference
Please forward widely. First abstract deadline is August 15.
Unite For Sight 6th Annual Global Health & Development Conference
"Achieving Global Goals Through Innovation"
http://www.uniteforsight.org/
When: April 18-19, 2009
Where: Yale University, New Haven, Connecticut, USA
What: Join 2,500 conference participants for a stimulating international conference
As Featured On CNN: The Unite For Sight Conference Is What CNN Calls "A Meeting Of Minds"
NOW OPEN: Registration and Abstract Submission http://www.uniteforsight.org/conference (First abstract deadline is August 15 (oral presentation deadline and early bird poster presentation deadline)
200 Speakers, Including Keynote Addresses by Dr. Jeffrey Sachs and Dr. Sonia Sachs
Register For Conference: REGISTER BY JULY 31 TO SECURE LOWEST RATE. Rate escalates each month.
Who is eligible to submit an abstract? Anyone may submit an abstract. Abstract submitters range from students to professionals.
Who should attend? Anyone interested in international health, public health, international development, medicine, nonprofits, eye care, philanthropy, microfinance, social entrepreneurship, bioethics, economics, anthropology, health policy, advocacy, environmental health, service-learning, medical education, and public service.
Keynote Addresses
- Jeffrey Sachs, PhD, Director of Earth Institute at Columbia University; Quetelet Professor of Sustainable Development, Professor of Health Policy and Management, Columbia University; Special Advisor to Secretary-General of the United Nations Ban Ki-moon
- Sonia Sachs, MD, MPH, Health Coordinator, Millennium Villages
200 Featured Speakers (Listed Below Are The Speakers Confirmed Thus Far)
Sam Abbenyi, MD, MSc, Director, Programs and Logistics, International Trachoma Initiative
Jane Aronson, MD, Director, International Pediatric Health Services; Founder and Executive Executive Officer, Worldwide Orphans Foundation (WWO); Clinical Assistant Professor of Pediatrics, Weill Medical College of Cornell University
Thomas Baah, MD, MSc, Ophthalmologist, Our Lady of Grace Hospital, Ghana
Richard Baraniuk, PhD, Founder, Connexions; Victor E. Cameron Professor, Electrical and Computer Engineering, Rice University
Paul Berman, OD, FAAO, Senior Global Clinical Advisor and Founder, Special Olympics Lions Clubs, International Opening Eyes
David Bloom, Chair, Department of Global Health and Population; Clarence James Gamble Professor of Economics and Demography, Department of Global Health and Population, Harvard School of Public Health
Peter Bourne, MA, MD, Visiting Scholar, Oxford University; Vice Chancellor Emeritus, St. George's University; Formerly Special Assistant to the President of the United States for Health Issues; Chair, Medical Education Cooperation with Cuba (MEDICC)
Ronald Braswell, MD, MS, Department of Ophthalmology, University of Alabama-Birmingham
Harry Brown, MD, Founder, Surgical Eye Expeditions (SEE) International
Richard Bucala, MD, PhD, Professor of Medicine, Pathology, and Epidemiology and Public Health, Yale University School of Medicine
James Clarke, MD, Ophthalmologist and Medical Director, Crystal Eye Clinic, Ghana
Emmanuel d'Harcourt, Senior Child Survival Technical Advisor, International Rescue Committee
Margaret Duah-Mensah, RN, ON, Ophthalmic Nurse, Crystal Eye Clinic, Ghana
Dabney Evans, MPH, Executive Director, Emory University Institute of Human Rights; Lecturer, Hubert Department of Global Health, Rollins School of Public Health at Emory University
Susan Forster, MD, Associate Clinical Professor, Department of Medical Studies, Department of Ophthalmology, Yale School of Medicine; Chief, Ophthalmology, Yale University Health Services
Stanley O. Foster, MD, MPH, Professor, Hubert Department of Global Health Rollins School of Public Health, Emory University
James Fraser, MA, Co-Founder and Executive Director, Dignitas International
Ulrick Gaillard, JD, CEO, The Batey Relief Alliance
Gannon Gillespie, Director of US Operations, Tostan
Susan Hayes, MD, President and CEO, Interplast
Scott Hillstrom, Chairman of the Board, CEO and Co-Founder, HealthStore Foundation
Samuel Ho, MD, Lui Hac Minh Professor of Surgery; Director, Asian Liver Center; Director, Liver Cancer Program, Stanford University School of Medicine
Debbie Humphries, MPH, PhD, Clinical Instructor, Division of Chronic Disease Epidemiology, Social and Behavioral Sciences Program, Yale University School of Medicine
Marcelo Jacobs-Lorena, PhD, Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins School of Public Health
Kaveh Khoshnood, PhD, Assistant Professor in Public Health Practice, Division of Epidemiology of Microbial Diseases, Yale School of Public Health
Karen King, MA, Elementary School Teacher, Reed Intermediate School; Unite For Sight Volunteer in Accra, Ghana
Laura Murray-Kolb, PhD, Assistant Professor, Center for Human Nutrition, Department of International Health, The Johns Hopkins University Bloomberg School of Public Health
Jamie Lachman, Clowns Without Borders
Doug Lawrence, Vice President/General Manager, BD Medical - Ophthalmic Systems
Robert Lawrence, MD, Center for A Livable future Professor; Professor of Environmental Health Sciences, Health Policy & International Health; Director, Center for a Livable Future, Department of Environmental Health Sciences; Johns Hopkins Bloomberg School of Public Health
Robert Malkin, PhD, Professor of Practice of Biomedical Engineering Director, Duke-Engineering World Health, Duke University
Charles MacCormack, PhD, President and CEO, Save The Children
John McGoldrick, JD, Senior Vice President, International AIDS Vaccine Initiative (IAVI)
Michelle McMurry, Director, Health, Biomedical Science and Society Initiative, The Aspen Institute
Benjamin Mason Meier, JD, LLM, MPhil, Public Health Law Project Manager, Center for Health Policy, IGERT-International Development and Globalization Fellow, Columbia University
Carol McLaughlin, MD, MPH, Global Health, Center for High Impact Philanthropy, School of Social Policy and Practice, University of Pennsylvania
Mini Murthy, MD, MPH, MS, Assistant Professor, Department of Behavioral Science and Community Health, Program Director Global Health, New York Medical College School of Public Health
Neal Nathanson, MD, Associate Dean, Global Health Programs, University of Pennsylvania School of Medicine
Edward O'Neil, Jr, MD, Omni Med
Santa Ono, PhD, Vice Provost for Academic Initiatives and Deputy Provost of Emory University; Professor, Department of Ophthalmology, Emory Eye Center
Robin Paetzold, MBA, Director, Global Programs, University of Iowa Carver College of Medicine
Steven C. Phillips, MD, MPH, Medical Director, Global Issues and Projects, Exxon Mobil Corporation
Suzanne Rainey, Forum One Communications
Susan Reef, MD, CDC
Steven Rothstein, President, Perkins School For The Blind
Lisa Russell, MPH, Filmmaker
Jinan Saaddine, MD, MPH, Medical Epidemiologist, Vision Health Initiative Team Leader, Division of Diabetes Translation, Centers for Disease Control and Prevention
Jeffrey Sachs, PhD, Director of Earth Institute at Columbia University; Quetelet Professor of Sustainable Development, Professor of Health Policy and Management, Columbia University; Special Advisor to Secretary-General of the United Nations Ban Ki-moon
Sonia Ehrlich Sachs, MD, MPH, Health Coordinator, Millennium Village Project
Sarwat Salim, MD, Assistant Professor of Ophthalmology, University of Tennessee-Memphis
Sarang Samal, Kalinga Eye Hospital, Orissa, India
Shlomit Sandler, MD, New York Eye and Ear Infirmary
Harshad Sanghvi, MD, Medical Director, JHPIEGO, Johns Hopkins University
Howard Schiffer, President and Founder, Vitamin Angels
Daniel D. Sedmak, MD, Director, Office of Global Health Education; Executive Vice Dean, College of Medicine; Executive Director, Center for Personalized Health care; Senior Associate Vice President, Office of Health Sciences, The Ohio State University
Bruce Shields, MD, Chair Emeritus, Yale Department of Ophthalmology
Kuldev Singh, MD, MPH, Professor of Ophthalmology, Stanford University School of Medicine
Ajit Sinha, MBBS, Founder and Director, AB Eye Institute; Former President, All India Ophthalmological Society
Pooja Sinha, MBBS, Ophthalmologist, AB Eye Institute, Patna, India
Satyajit Sinha, MBBS, Ophthalmologist, AB Eye Institute, Patna, India
D. Scott Smith, MD, MSc, DTM&H, Chief of Infectious Diseases and Geographic Medicine, Kaiser Redwood City Hospital
Janice K. Smith, MD, MPH, PAHO/WHO Collaborating Center for Training in International Health at UTMB
Georgia Sambunaris, MA, Senior Financial Markets Specialist, USAID
Chris Stout, PsyD, Founding Director, Center for Global Initiatives; Clinical Professor, College of Medicine, University of Illinois at Chicago
James C. Tsai, MD, Robert R. Young Professor and Chairman, Department of Ophthalmology and Visual Sciences, Yale University School of Medicine; Chief of Ophthalmology, Yale-New Haven Hospital
Philippe Van Denbossche, Executive Director, Raising Malawi
Harold Varmus, MD, President and Chief Executive, Memorial Sloan-Kettering Cancer Center; Former Director of the NIH; Nobel Prize Recipient
Seth Wanye, MD, Ophthalmologist, Eye Clinic of Tamale Teaching Hospital, Ghana
Tanya Whitehead, PhD, Research Associate Professor, University of Missouri - Kansas City
David Zakus, BSc, MES, MSc, PhD, Director, Centre for International Health; Associate Professor, Department of Public Health Sciences; Associate Professor, Department of Health Policy, Management and Evaluation; Faculty of Medicine, University of Toronto, Canada
Debrework Zewdie, Director, Global HIV/AIDS Program of the World Bank Human Development Network World Bank
Ministry of Health, Maldives Recruiting Specialist
Dear Doctor,
Ministry of Health, Maldives, is looking for the following specilist for their island hospitals.
1) Anaesthetist
2) Gynacologist
3) Paediatricians
4) Generl Surgeons
Free Family accommodation (Two Bedroom furnished)
Tax Free Salary of Rs.90,000 to Rs.1,20,000/- and above
Free Annual Ticket to home town etc.
and a chance to live in a Tourist country. (Maldives is one of the most beutiful countries and known for its beaches and other natural beauty.
If you are interested pl contact ASAP.
Regards
Career Mine - Human Resource Consultants
216-B, Near Father Agnel School,
Gautam Nagar, NEw Delhi - 110049.
011-26852488, 26852568, 9999310551, 9899855530,
medicaljobs@careermines.com
Ministry of Health, Maldives, is looking for the following specilist for their island hospitals.
1) Anaesthetist
2) Gynacologist
3) Paediatricians
4) Generl Surgeons
Free Family accommodation (Two Bedroom furnished)
Tax Free Salary of Rs.90,000 to Rs.1,20,000/- and above
Free Annual Ticket to home town etc.
and a chance to live in a Tourist country. (Maldives is one of the most beutiful countries and known for its beaches and other natural beauty.
If you are interested pl contact ASAP.
Regards
Career Mine - Human Resource Consultants
216-B, Near Father Agnel School,
Gautam Nagar, NEw Delhi - 110049.
011-26852488, 26852568, 9999310551, 9899855530,
medicaljobs@careermines.com
ordinance to protect the Medical profession
Ordinance providing protection to medical professionals and institutions in Tamilnadu comes to effect
The Hindu dated 21-07-08
Friday, July 4, 2008
Human Genetics
)
IMPORTANT : This is just for information. This book has not been read or reviewed by US
A Gardner, R.T. Howell and T. Davies 8130906023 2008 PB Viva Books Private Limited 216 pp 7.25 x 9.5" Single Colour Rs. 325.00
Description: Human Genetics covers all aspects of genetics of relevance to medical scientists including mutations, chromosomal abnormalities, inheritance patterns, genetic counselling, cancer genetics, prenatal diagnosis and gene therapy. The authors also examine in detail cystic fibrosis, Huntington’s chorea and muscular dystrophy. This book is designed as a concise textbook for undergraduate biomedical science students, and it offers the following key features: • Learning objectives to help guide understanding • Core knowledge written in a style that encourages students to think around the subject rather than just learning the facts, and with numerous illustrations • Key concepts and facts summarised to aid revision • Self-assessment questions and answers to test understanding • Further reading list to guide students to more detailed coverage if required.
Contents: Preface • Series preface • Acknowledgements • Part One: Mechanisms of Disease • Structure and organization of DNA • How normal genes work • Mechanisms of disease • Part Two: Diagnosis of Disease • Patterns of inheritance • Cytogenetics • Molecular cytogenetics • Molecular genetics • Cancer genetics • Part Three: Prevention of Disease • Prenatal diagnosis • Genetic counselling • Appendix: Glossary of disorders • Answers to self-assessment questions • Index.
About the Authors: Anne Gardner is Principal Clinical Scientist of Molecular Genetics.
Rodney T. Howell and Teresa Davies are consultant Clinical Scientists (Cytogenetics)
Target Audience: Undergraduate biomedical science students.
Contents: Preface • Series preface • Acknowledgements • Part One: Mechanisms of Disease • Structure and organization of DNA • How normal genes work • Mechanisms of disease • Part Two: Diagnosis of Disease • Patterns of inheritance • Cytogenetics • Molecular cytogenetics • Molecular genetics • Cancer genetics • Part Three: Prevention of Disease • Prenatal diagnosis • Genetic counselling • Appendix: Glossary of disorders • Answers to self-assessment questions • Index.
About the Authors: Anne Gardner is Principal Clinical Scientist of Molecular Genetics.
Rodney T. Howell and Teresa Davies are consultant Clinical Scientists (Cytogenetics)
Target Audience: Undergraduate biomedical science students.
| Tel: 42242200, 23258325, 23283121 Fax: 42242240 email : vivadelhi@vivagroupindia.net |
| Tel: 27721273, 27721274 Telefax: 27721273 email: vivamumbai@vivagroupindia.net |
| Tel: 28290304, 28294241 email: vivachennai@vivagroupindia.net |
| Tel: 22816713, 22836381 email : vivakolkata@vivagroupindia.net |
| Basavanagudi, Bangalore -560 004 Tel: 6607409, email: vivabangalore@vivagroupindia |
| Tel: 27564481 Telefax: 27564482 email: vivahyderabad@vivagroupindia |
| First Floor, Beevi Tower, SRM Road, Kaloor, Kochi, Kerala - 682 018 Tel: 0484-2403055, 0484-2403056 email: vivakochi@vivagroupindia.net |
Molecular Genetics
)
IMPORTANT : This is just for information. This book has not been read or reviewed by US
J.T. Hancock 813090604X 2008 PB Viva Books Private Limited 192 pp 6x9" Single Colour Rs. 295.00
Description: Molecular Genetics provides a basic understanding of genes and how they are used as a source of information for the production of proteins. The book also describes the techniques used in molecular genetics research, from mapping of genes, through gene cloning, PCR and sequencing, to give the reader an insight into the practical details. This book is designed as a concise textbook for undergraduate biomedical science students, and it offers the following key features: • Learning objectives to help guide understanding • Core knowledge written in a style that encourages students to think around the subject rather than just learning the facts, and with numerous illustrations • Key concepts and facts summarised to aid revision • Self-assessment questions and answers to test understanding • Further reading list to guide students to more detailed coverage if required.
Contents: Preface • Series preface • Part One: Molecular Biology • Introduction • What is DNA • Genes • Genome structure • Transcription and RNA • Translation and genetic code • Control of gene expression • Inheritance • Part Two: Techniques Used in Molecular Genetics
• Mapping of genes • Gel electrophoresis and blotting • Gene cloning and gene libraries
• Polymerase chain reaction(PCR) • Sequencing and sequence analysis • The future of molecular genetics: biotechnology, transgenics and gene therapy • Answers to self-assessment questions • Index.
About the Author: J.T. Hancock is senior Lecturer in Molecular Cell Biology, University of theWest of England, Bristol, UK
Target Audience: Undergraduate Biomedical Science Students.
Contents: Preface • Series preface • Part One: Molecular Biology • Introduction • What is DNA • Genes • Genome structure • Transcription and RNA • Translation and genetic code • Control of gene expression • Inheritance • Part Two: Techniques Used in Molecular Genetics
• Mapping of genes • Gel electrophoresis and blotting • Gene cloning and gene libraries
• Polymerase chain reaction(PCR) • Sequencing and sequence analysis • The future of molecular genetics: biotechnology, transgenics and gene therapy • Answers to self-assessment questions • Index.
About the Author: J.T. Hancock is senior Lecturer in Molecular Cell Biology, University of theWest of England, Bristol, UK
Target Audience: Undergraduate Biomedical Science Students.
| Tel: 42242200, 23258325, 23283121 Fax: 42242240 email : vivadelhi@vivagroupindia.net |
| Tel: 27721273, 27721274 Telefax: 27721273 email: vivamumbai@vivagroupindia.net |
| Tel: 28290304, 28294241 email: vivachennai@vivagroupindia.net |
| Tel: 22816713, 22836381 email : vivakolkata@vivagroupindia.net |
| Basavanagudi, Bangalore -560 004 Tel: 6607409, email: vivabangalore@vivagroupindia |
| Tel: 27564481 Telefax: 27564482 email: vivahyderabad@vivagroupindia |
| First Floor, Beevi Tower, SRM Road, Kaloor, Kochi, Kerala - 682 018 Tel: 0484-2403055, 0484-2403056 email: vivakochi@vivagroupindia.net |
New Clinical Genetics
IMPORTANT : This is just for information. This book has not been read or reviewed by US
Andrew Read & Dian Donnai 1904842313 PB 2007 Scion Publishing 450 pp Rs. 795.00
Description: New Clinical Genetics provides all those involved in medical genetics with a unique clinical guide based on post-genomic technologies. Whether you are a medical student, a genetic counselor, or a clinical geneticist, this book offers something new, with descriptions of the latest molecular tests linked to realistic cases to show how modern genetics works in the clinic.
Each chapter answers common questions, such as:
What can we learn from a family history? • How do genes work? • How can we check a patient's DNA for gene mutations? • What is epigenetics? • Should we be testing for genetic susceptibility to common diseases? • What can we do about genetic disease? • Within every chapter, the authors have integrated realistic case studies with basic human genetics to allow readers to see how their understanding can be applied in clinical practice. This approach also allows readers to choose different routes through the book.
Those who prefer a problem-based approach can work through the individual case studies and Investigations of patients sections and be introduced to the genetics as it relates to each case, using the science sections as reference material.
Those who prefer a more didactic approach can concentrate on the science in the Background and Summary and extension sections, referring to the Case Studies for illustrations of the practical application of genetics in a clinical setting.
All chapters conclude with self-assessment questions so that readers can check that they have mastered the material.
Contents:
• What can we learn from a family history?; Case studies; Background- How to take a family history and draw a pedigree; Investigations of patients; Summary and extension- the art of pedigree interpretation; Penetrance and expressivity-pitfalls in inheritance and counselling; Rarer modes of inheritance; Mosaicism; References; Self-assessment questions •
How can a patient’s chromosomes be studied? ; Case studies; Background- why clinicians need to know about chromosomes; How are chromosomes studied? Material for chromosome analysis; Chromosomes and their abnormalities; Chromosome abnormalities- Why do we have chromosomes? The behaviour of chromosomes during cell division; Investigations of patients; Summary and extension- What are chromosomes?; Numerical and structural abnormalities; Balanced and unbalanced abnormalities; Constitutional and mosaic abnormalities; Self- assessment questions •
• How do genes work? ; Case studies; Background; Investigations of patients; Summary and extension- Some chemistry; Genes are much bigger than you think; Switching genes on and off- transcription and its controls; One gene often encodes more than one protein; What does all our DNA do? A hidden RNA world; References; Self-assessment questions •
• How can a patient’s DNA be studied? ; Case studies; Background; Investigations of patients; Summary and extension- Quantitative PCR; Real-time PCR; Testing RNA; Testing protein; Chromosome painting; References; Self-assessment questions •
How can we check a patient’s DNA for gene mutations?; Case studies; Background; Investigations of patients; Summary and extension- The three questions; Mutation detection using chips; Other methods for genotyping or sequencing DNA; Methods for scanning a gene for any sequence change; Methods for detecting deletions or duplication of whole exons •
• What do mutations do?; Case studies; Background; Investigations of patients; Summary and extension; Loss of function and gain of function changes; Dominant or recessive?; Understanding the phenotype; Genotype-phenotype correlations; Predicting the phenotype: the problem of novel mis-sense changes; Dosage sensitivity and the pathology of chromosomal abnormalities; Somatic mutations; How do mutations arise? Self-assessment questions
• What is epigenetics?; Case questions; Background; Investigations of patients; Summary and extension- CpG as a mutation hotspot; X-inactivation has implications for women who carry an X- autosome translocation; Other imprinting-related disorders; What is the purpose of imprinting? How important are epigenetic effects?
• How do genes affect our metabolism, drug responses and immune system?; Case studies; Background; Investigations of patients; Summary and Extension; Inborn errors of metabolism; Pharmacogenetics; Immunogenetics; References;
• How do researchers identify genes for mendelian diseases?; Background; Investigations of patients; Summary and extension- What is the chance the offspring of a consanguineous marriage will have a recessive disease?; Can we abolish genetic disease • Why are some conditions common and others rare?
• When is screening useful? ; Case studies; Background; Investigations of patients; Summary and extension: What conditions should we screen for? The population attributable risk; Criteria used by the UK National Screening Committee; Lifestyle genetic testing;
• Is cancer genetic?; Summary and extension- Hereditary non-polyposis colon cancer; The multistage development of cancer; Epigenetics in cancer; Are familial breast and colon cancer really multifactorial conditions? Expression profiling of tumors;
• Should we be testing for genetic susceptibility to common disease?; Case studies; Background; Investigations of patients; Summary and extension: Problems with association studies; A resource for association studies; the HapMap project; A risk in association studies: everything depends on the Common Disease- Common Variant hypothesis; References; Self- assessment questions
• What can we do about genetic disease?; Case studies; Background; Investigations of patients; Summary and extension- Gene therapy; stem cell therapy; Diagnosis and counseling; Testing; Treatment • Guidance for self-assessment questions
• Index • Case notes
About the authors: Andrew Read (PhD, FRCPath, FMedSci) is Professor of Human Genetics at the University of Manchester.
Dian Donnai (FRCP, FRCPCH, FMedSci) is Professor of Medical Genetics at the University of Manchester and Consultant Clinical Geneticist in the NW Regional Genetics Service.
Target Audience: Medical students, genetic counsellors, clinical geneticists.
Each chapter answers common questions, such as:
What can we learn from a family history? • How do genes work? • How can we check a patient's DNA for gene mutations? • What is epigenetics? • Should we be testing for genetic susceptibility to common diseases? • What can we do about genetic disease? • Within every chapter, the authors have integrated realistic case studies with basic human genetics to allow readers to see how their understanding can be applied in clinical practice. This approach also allows readers to choose different routes through the book.
Those who prefer a problem-based approach can work through the individual case studies and Investigations of patients sections and be introduced to the genetics as it relates to each case, using the science sections as reference material.
Those who prefer a more didactic approach can concentrate on the science in the Background and Summary and extension sections, referring to the Case Studies for illustrations of the practical application of genetics in a clinical setting.
All chapters conclude with self-assessment questions so that readers can check that they have mastered the material.
Contents:
• What can we learn from a family history?; Case studies; Background- How to take a family history and draw a pedigree; Investigations of patients; Summary and extension- the art of pedigree interpretation; Penetrance and expressivity-pitfalls in inheritance and counselling; Rarer modes of inheritance; Mosaicism; References; Self-assessment questions •
How can a patient’s chromosomes be studied? ; Case studies; Background- why clinicians need to know about chromosomes; How are chromosomes studied? Material for chromosome analysis; Chromosomes and their abnormalities; Chromosome abnormalities- Why do we have chromosomes? The behaviour of chromosomes during cell division; Investigations of patients; Summary and extension- What are chromosomes?; Numerical and structural abnormalities; Balanced and unbalanced abnormalities; Constitutional and mosaic abnormalities; Self- assessment questions •
• How do genes work? ; Case studies; Background; Investigations of patients; Summary and extension- Some chemistry; Genes are much bigger than you think; Switching genes on and off- transcription and its controls; One gene often encodes more than one protein; What does all our DNA do? A hidden RNA world; References; Self-assessment questions •
• How can a patient’s DNA be studied? ; Case studies; Background; Investigations of patients; Summary and extension- Quantitative PCR; Real-time PCR; Testing RNA; Testing protein; Chromosome painting; References; Self-assessment questions •
How can we check a patient’s DNA for gene mutations?; Case studies; Background; Investigations of patients; Summary and extension- The three questions; Mutation detection using chips; Other methods for genotyping or sequencing DNA; Methods for scanning a gene for any sequence change; Methods for detecting deletions or duplication of whole exons •
• What do mutations do?; Case studies; Background; Investigations of patients; Summary and extension; Loss of function and gain of function changes; Dominant or recessive?; Understanding the phenotype; Genotype-phenotype correlations; Predicting the phenotype: the problem of novel mis-sense changes; Dosage sensitivity and the pathology of chromosomal abnormalities; Somatic mutations; How do mutations arise? Self-assessment questions
• What is epigenetics?; Case questions; Background; Investigations of patients; Summary and extension- CpG as a mutation hotspot; X-inactivation has implications for women who carry an X- autosome translocation; Other imprinting-related disorders; What is the purpose of imprinting? How important are epigenetic effects?
• How do genes affect our metabolism, drug responses and immune system?; Case studies; Background; Investigations of patients; Summary and Extension; Inborn errors of metabolism; Pharmacogenetics; Immunogenetics; References;
• How do researchers identify genes for mendelian diseases?; Background; Investigations of patients; Summary and extension- What is the chance the offspring of a consanguineous marriage will have a recessive disease?; Can we abolish genetic disease • Why are some conditions common and others rare?
• When is screening useful? ; Case studies; Background; Investigations of patients; Summary and extension: What conditions should we screen for? The population attributable risk; Criteria used by the UK National Screening Committee; Lifestyle genetic testing;
• Is cancer genetic?; Summary and extension- Hereditary non-polyposis colon cancer; The multistage development of cancer; Epigenetics in cancer; Are familial breast and colon cancer really multifactorial conditions? Expression profiling of tumors;
• Should we be testing for genetic susceptibility to common disease?; Case studies; Background; Investigations of patients; Summary and extension: Problems with association studies; A resource for association studies; the HapMap project; A risk in association studies: everything depends on the Common Disease- Common Variant hypothesis; References; Self- assessment questions
• What can we do about genetic disease?; Case studies; Background; Investigations of patients; Summary and extension- Gene therapy; stem cell therapy; Diagnosis and counseling; Testing; Treatment • Guidance for self-assessment questions
• Index • Case notes
About the authors: Andrew Read (PhD, FRCPath, FMedSci) is Professor of Human Genetics at the University of Manchester.
Dian Donnai (FRCP, FRCPCH, FMedSci) is Professor of Medical Genetics at the University of Manchester and Consultant Clinical Geneticist in the NW Regional Genetics Service.
Target Audience: Medical students, genetic counsellors, clinical geneticists.
| |
| Tel: 42242200, 23258325, 23283121 Fax: 42242240 email : vivadelhi@vivagroupindia.net |
| Tel: 27721273, 27721274 Telefax: 27721273 email: vivamumbai@vivagroupindia.net |
| Tel: 28290304, 28294241 email: vivachennai@vivagroupindia.net |
| Tel: 22816713, 22836381 email : vivakolkata@vivagroupindia.net |
| Basavanagudi, Bangalore -560 004 Tel: 6607409, email: vivabangalore@vivagroupindia |
| Tel: 27564481 Telefax: 27564482 email: vivahyderabad@vivagroupindia |
| First Floor, Beevi Tower, SRM Road, Kaloor, Kochi, Kerala - 682 018 Tel: 0484-2403055, 0484-2403056 email: vivakochi@vivagroupindia.net |
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